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KMID : 0616120170480030243
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Korean Journal of Pharmacognosy
2017 Volume.48 No. 3 p.243 ~ p.247
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Quantification of Caffeoylquinic Acids and the Effect of the Cacalia hastata var. orientalis Extract on Acetylcholinesterase Activity and Peroxynitrite Concentration
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Nugroho Agung
Choi Jae-sue
Park Hee-Juhn
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Abstract
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To find the anti-Alzheimer`s activity of Cacalia hastata var. orientalis (Compositae), caffeoylquinic acids were analyzed in this plant by HPLC and the inhibitory activities of the extract on cholinesterases including acetylcholinesterase (AChE) and butyrylcholinesterse (BChE) and peroxynitrite (ONOO-) were assayed. Sum of caffeoylquinic acids in the 80% MeOH extract was quantitatively higher in leaves (35.8% of the extract) than in stems (3.7%). The compound, 3,5-dicaffeoylquinic acid, was contained in the highest amount in the leaf (44.32 mg/g dry weight). The IC50s of the 80% MeOH extract were shown to be 67.45 μg/ml for AChE, and 8.59 μg/ml (for ONOO-), respectively, suggesting that the leaves would have the anti-Alzheimer`s activity due to the high content of caffeoylquinic acids.
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KEYWORD
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Cacalia hastata var. orientalis , Compositae , Caffeoylquinic acids , Acetylcholinesterase , Peroxynitrite , Anti-Alzheimer
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